Chromatin: Beads on a String or String on Beads?
نویسندگان
چکیده
LOCAL REMODELING OF chromatin is a key step in the transcriptional activation of genes. Dynamic changes in the nucleosomal packaging of DNA must occur to allow transcriptional proteins contact with the DNA template. The realization that the proteins that regulate the modification of chromatin are themselves disrupted in many leukemic chromosomal rearrangements has generated new excitement in the study of chromatin structure. Recent reports have kindled the hope that pharmacological manipulation of chromatin remodeling might develop into a potent and specific strategy for the treatment of these leukemias. In this review, we will discuss the structure of chromatin and the mechanisms by which cells remodel chromatin, alteration of these pathways in leukemias, and therapeutic approaches.
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